Older age is the main risk factor for cancer. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors.
This page covers other factors with the best evidence of an association with cancer risk; this list is not exhaustive.
See our other pages for general information about cancer, or ways to reduce your risk.
View our latest cancer statistics including key stats, in-depth explanations and raw data on cancer incidence, mortality, survival, risk, and diagnosis and treatment.
View full A-Z cancer statisticsSee information and explanations on terminology used for statistics and reporting of cancer, and the methods used to calculate some of our statistics.
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Find out more about the sources which are essential for our statistics
Lifetime risk estimates calculated by the Cancer Intelligence Team at Cancer Research UK 2023.
Sasieni PD, Shelton J, Ormiston-Smith N, et al. What is the lifetime risk of developing cancer?: The effect of adjusting for multiple primaries. Br J Cancer, 2011.105(3): p.460-5
Brown KF, Rumgay H, Dunlop C, et al. The fraction of cancer attributable to known risk factors in England, Wales, Scotland, Northern Ireland, and the UK overall in 2015. British Journal of Cancer 2018.
International Agency for Research on Cancer. List of Classifications by cancer sites with sufficient or limited evidence in humans, Volumes 1 to 122*. Accessed October 2018.
Lauby-Secretan B, Scoccianti C, Loomis D, et al. Body Fatness and Cancer--Viewpoint of the IARC Working Group. N Engl J Med. 2016 Aug 25;375(8):794-8.
World Cancer Research Fund / American Institute for Cancer Research. Continuous Update Project Findings & Reports. Accessed October 2016.
International Agency for Research on Cancer. List of Classifications by cancer sites with sufficient or limited evidence in humans, Volumes 1 to 122. Accessed August 2018.
Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 2001;49:347-53.
Palli D, Masala G, Del Giudice G, et al. CagA+ Helicobacter pylori infection and gastric cancer risk in the EPIC-EURGAST study. IJC 2007;120:859-67.
Huang JQ, Zheng GF, Sumanac K, et al. Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology 2003;125:1636-44.
Lee Y, Chiang T, Chou C, et al. Association Between Helicobacter pylori Eradication and Gastric Cancer Incidence: A Systematic Review and Meta-analysis. Gastroenterology 2016;150(5):1113-1124.e5.
Parkin DM. The global health burden of infection-associated cancers in the year 2002. IJC 2006;118:3030-44.
Vyse AJ, Gay NJ, Hesketh LM, et al. The burden of Helicobacter pylori infection in England and Wales. Epidemiol Infect 2002;128:411-7.
International Agency for Research on Cancer. List of Classifications by cancer sites with sufficient or limited evidence in humans, Volumes 1 to 116*. Accessed January 2017.
La Torre G, Chiaradia G, Gianfagna F, et al. Smoking status and gastric cancer risk: an updated meta-analysis of case-control studies published in the past ten years. Tumori 2009;95:13-22.
Ladeiras-Lopes R, Pereira AK, Nogueira A, et al. Smoking and gastric cancer: systematic review and meta-analysis of cohort studies. Cancer Causes Control 2008;19:689-701.
Tredaniel J, Boffetta P, Buiatti E, et al. Tobacco smoking and gastric cancer: review and meta-analysis. IJC 1997;72:565-73.
Lee PN, Hamling J. Systematic review of the relation between smokeless tobacco and cancer in Europe and North America. BMC Med 2009;7:36.
Boffetta P, Aagnes B, Weiderpass E, et al. Smokeless tobacco use and risk of cancer of the pancreas and other organs. IJC 2005;114:992-5.
World Cancer Research Fund / American Institute for Cancer Research. Continuous Update Project Findings & Reports. Accessed October 2018.
Kyrgiou M, Kalliala I, Markozannes G, et al. Adiposity and cancer at major anatomical sites: umbrella review of the literature. BMJ 2017;:j477.
Du X, Hidayat K, Shi B. Abdominal obesity and gastroesophageal cancer risk: systematic review and meta-analysis of prospective studies. Bioscience Reports 2017;37(3):BSR20160474.
International Agency for Research on Cancer. List of Classifications by cancer sites with sufficient or limited evidence in humans, Volumes 1 to 122. Accessed October 2018.
Murphy G, Pfeiffer R, Camargo MC, et al. Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location. Gastroenterology 2009;137:824-33.
Camargo MC, Murphy G, Koriyama C, et al. Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis. BJC 2011;105:38-43.
Boysen T, Friborg J, Stribolt K, et al. Epstein-Barr virus-associated gastric carcinoma among patients with pernicious anemia. Int J Cancer. 2011 Dec 1;129(11):2756-60.
Peng WJ, Jia XJ, Wei BG, et al. Stomach cancer mortality among workers exposed to asbestos: a meta-analysis. J Cancer Res Clin Oncol 2014.
Welling R, Beaumont JJ, Petersen SJ, et al. Chromium VI and stomach cancer: a meta-analysis of the current epidemiological evidence. Occup Environ Med 2015;72(2):151-159.
Zhao Z, Yin Z, Zhao Q. Red and processed meat consumption and gastric cancer risk: a systematic review and meta-analysis. Oncotarget 2017;8(18).
Gonzalez CA, Jakszyn P, Pera G, et al. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). JNCI 2006;98:345-54.
Kim HJ, Lim SY, Lee JS, et al. Fresh and pickled vegetable consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies. Cancer Sci 2010;101:508-16.
Ren JS, Kamangar F, Forman D, et al. Pickled Food and Risk of Gastric Cancer--a Systematic Review and Meta-analysis of English and Chinese Literature. Cancer Epidemiol Biomarkers Prev 2012.
D'Elia L, Rossi G, Ippolito R, et al. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr. 2012 Aug;31(4):489-98.
Shikata K, Kiyohara Y, Kubo M, et al. A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: the Hisayama study. IJC 2006;119:196-201.
Peleteiro B, Lopes C, Figueiredo C, et al. Salt intake and gastric cancer risk according to Helicobacter pylori infection, smoking, tumour site and histological type. BJC 2011;104:198-207.
Ge S, Feng X, Shen L, et al. Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies. Gastroenterol Res Pract 2012;2012:808120.
Wang XQ, Terry PD, Yan H. Review of salt consumption and stomach cancer risk: epidemiological and biological evidence. World J Gastroenterol 2009;15:2204-13.
Bagnardi V, Rota M, Botteri E, et al. Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. Br J Cancer. 2015 Feb 3;112(3):580-93.
He Z, Zhao T, Xu H, et al. Association between alcohol consumption and the risk of gastric cancer: a meta-analysis of prospective cohort studies. Oncotarget 2017;8(48).
Sona M, Myung S, Park K, et al. Type 1 diabetes mellitus and risk of cancer: a meta-analysis of observational studies. Japanese Journal of Clinical Oncology 2018;48(5):426-433.
Miao Z, Xu H, Xu Y, et al. Diabetes mellitus and the risk of gastric cancer: a meta-analysis of cohort studies. Oncotarget 2017;8(27).
Franciosi M, Lucisano G, Lapice E, et al. Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review. PLoS One. 2013;8(8):e71583.
