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Anal cancer risk

Older age is the main risk factor for cancer. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors.

This page covers other factors with the best evidence of an association with cancer risk; this list is not exhaustive.

See our other pages for general information about cancer, or ways to reduce your risk.

More anal cancer statistics

Incidence

Mortality

Statistics by cancer type

View our latest cancer statistics including key stats, in-depth explanations and raw data on cancer incidence, mortality, survival, risk, and diagnosis and treatment.

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Cancer stats explained

See information and explanations on terminology used for statistics and reporting of cancer, and the methods used to calculate some of our statistics.

Local cancer statistics

Go to local cancer statistics - search profiles by area, constituency or health board in the UK.

Go to devolved nations overview for an overview of Wales, Scotland or Northern Ireland.

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Acknowledgements

We are grateful to the many organisations across the UK which collect, analyse, and share the data which we use, and to the patients and public who consent for their data to be used.

Find out more about the sources which are essential for our statistics

References

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    Lifetime risk estimates calculated by the Cancer Intelligence Team at Cancer Research UK 2023.

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    Estève J, Benhamou E, Raymond L. Statistical methods in cancer research. Volume IV. Descriptive epidemiology. IARC Sci Publ. 1994;(128):1-302.

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    International Agency for Research on Cancer. List of Classifications by cancer sites with sufficient or limited evidence in humans, Volumes 1 to 122*. Accessed August 2018.

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    Vaccarella S, Franceschi S, et al. Sexual behavior, condom use, and human papillomavirus: pooled analysis of the IARC human papillomavirus prevalence surveys. Cancer Epidemiology Biomarkers & Prevention 2006;;15(2):326-33.

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    World Cancer Research Fund/American Institute for Cancer Research. Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective(PDF). Washington DC: AICR; 2007.

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    Grulich AE, van Leeuwen MT, Falster MO, et al. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis Lancet 2007;370(9581):59-67.

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    Shiels MS, Cole SR, Kirk GD, et al. A meta-analysis of the incidence of non-AIDS cancers in HIV-infected individual. J Acquir Immune Defic Syndr 2009;52(5):611-22.

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    Silverberg MJ, Lau B, Justice AC, et al. Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America. Clin Infect Dis 2012;54(7):1026-34.

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    Grulich AE, Poynten IM, Machalek DA, et al. The epidemiology of anal cancer. Sex Health. 2012 Dec;9(6):504-8.