Living with the effects of hormone therapy for prostate cancer
Hormone therapy lowers the levels of testosterone. This can cause thinning and weakening of the bones.
Make sure your diet has enough calcium and vitamin D. This helps to keep your bones healthy.
Your doctor may suggest you take medicines called bisphosphonates if you have been diagnosed with bone thinning (osteoporosis).
for prostate cancer can lower the levels of sex hormones (testosterone) in the blood. This can cause different side effects including problems with your bones.
Hormone therapy lowers the levels of testosterone. This can cause thinning and weakening of the bones.
Make sure your diet has enough calcium and vitamin D. This helps to keep your bones healthy.
Your doctor may suggest you take medicines called bisphosphonates if you have been diagnosed with bone thinning (osteoporosis).
Prostate cancer usually needs testosterone to grow. Hormone therapy aims to stop:
the testicles from making testosterone
testosterone from reaching cancer cells
Bone loss is a common side effect of hormone therapy. But how much bone loss you might have varies from person to person. And not all hormone treatments cause bone loss.
Your nurse or doctor will tell you if they think you might be at risk of bone loss. Especially, if you are at high risk of having problems with your spine.
Find out more about hormone therapy for prostate cancer
Getting older can also cause your bones to get thinner and weaker. Thinner bones are more at risk of breaking (fracturing). This bone thinning is called osteoporosis.
Your doctor will assess if you are at high risk of bone loss. Getting older and having cancer treatment can increase the risk of bone loss. You'll have a bone density scan (also called a DEXA or DXA scan) if you are at high risk.
There are different things you can do to reduce your risk of bone loss. These include:
making sure your diet has enough calcium and vitamin D
avoiding caffeine, alcohol and smoking
exercising regularly
taking medicines called
Adults should generally have 700mg of calcium a day. People with osteoporosis should aim for 1000mg a day.
Dairy products such as milk, cheese and yoghurt contain calcium. Some foods have added calcium. Check food labels to see how much calcium they contain. Milk substitutes such as soya or rice milk usually do not contain as much calcium as dairy products.
You can also get calcium from:
green vegetables (cabbage, broccoli and okra)
soya products including tofu
tinned fish with bones like sardines, salmon and pilchards
nuts and dried fruit
fortified breakfast cereals
bread and foods made from flour
tap water
Calcium supplements are available. Dietitians recommend that you do not have more than 1500mg of calcium. This total calcium could come from your diet or a combination of diet and supplements. Too much calcium can cause tummy (abdominal) pain and diarrhoea.
Your body needs vitamin D to absorb calcium. Sunlight helps the body to make vitamin D. A daily short walk in natural sunlight makes enough vitamin D for most people. Vitamin D is also found in margarine, oily fish and egg yolks. Public Health England recommends that in winter and autumn, people in the UK should consider taking a daily supplement of vitamin D containing 10 micrograms. This is because it is difficult for people to get enough vitamin D through their diet.
Your doctor or nurse can refer you to a dietitian to check that your diet has enough calcium and vitamin D to keep your bones healthy.
Drinking alcohol increases the risk of bone loss (osteoporosis). National guidelines recommend that you don't drink more than 14 units of alcohol per week. Caffeine can cause calcium to be lost in the urine.
Exercise
Exercise is important for bone health but it needs to be weight bearing exercise. This means that you are supporting your own weight with your legs and arms. This can strengthen muscles, improve posture, and could help with pain.
Many of us don’t do enough regular exercise. Bringing exercise into your daily life is the best way to make sure you get enough.
Tips:
Walking is good.
Household activities can help, such as cleaning, gardening, shopping or even going up and down stairs.
You could join an exercise group or class. It doesn’t have to be very energetic. Gentle controlled exercise such as Tai Chi can be good.
Although swimming doesn’t help, exercise classes in the swimming pool (aqua-aerobics) can. Walking and exercising in the pool is quite hard work because of the resistance of the water.
Bones naturally break down and repair themselves. Hormone therapy can weaken your bone and increase your risk of a bone breaking (fracture).
You might also have bisphosphonates if you have osteoporosis and are having hormone therapy.
You might also have bisphosphonates for pain if you have cancer that has spread to other parts of your body. This is metastatic or advanced prostate cancer. Bisphosphonates can help with bone pain.
Bisphosphonates move calcium cells from your blood stream into your bone. This helps to keep the bone strong. As you need to keep some calcium in your blood stream, your doctor may give you calcium tablets.
Bisphosphonates include:
alendronate tablets
risedronate tablets
zoledronic Acid (Zometa) - this is a drip that you have into your bloodstream
Denosumab is a different type of drug. It works by stopping the activity of bone cells called osteoclasts. Denosumab can increase bone density to help strengthen the bone. It can be used instead of bisphosphonates to help to reduce fractures in people whose cancer has spread.
It can be difficult coping with prostate cancer and its treatment. There is support available.
Find out about coping with prostate cancer
The Royal Osteoporosis Society has a lot of information about the causes, prevention and treatment of osteoporosis.
Last reviewed: 10 Sept 2025
Next review due: 10 Sept 2028
Hormone therapy for prostate cancer can affect the levels of your hormones. This can cause different side effects including hot flushes, swollen breasts, sleep disturbances and weight changes.
Prostate cancer usually depends on testosterone to grow. Hormone therapy blocks or lowers the amount of testosterone in the body.
Get practical and emotional support to help you cope with a diagnosis of prostate cancer, and life during and after treatment.
Prostate cancer is cancer of the prostate gland. The prostate gland is part of the male reproductive system, and is at the base of the bladder.
Prostate cancer is cancer that starts in the prostate gland. The prostate gland is found at the base of the bladder and is about the size of a walnut.

About Cancer generously supported by Dangoor Education since 2010. Learn more about Dangoor Education
What to ask your doctor about clinical trials.
Meet and chat to other cancer people affected by cancer.
Questions about cancer? Call freephone 0808 800 40 40 from 9 to 5 - Monday to Friday. Alternatively, you can email us.