Zoledronic acid (Zometa)

Zoledronic acid is a type of drug known as a ​bisphosphonate​. It is also called Zometa.

You might have zoledronic acid to:

• prevent problems with the bones such as breaks in the bones (fractures) in myeloma and cancers that have spread to the bone (metastatic cancer)

• prevent bone loss for people having ​aromatase inhibitors​

• lower high levels of calcium in the blood (​hypercalcaemia​), which can happen in secondary bone cancer 

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How do you have zoledronic acid?

Zoledronic acid is a clear liquid. You have it as a drip into your bloodstream (intravenously). 

The drip usually lasts about 15 minutes, but you might have it over a longer period. 

You might have treatment through a long plastic tube that goes into a large vein in your chest. The tube stays in place throughout the course of treatment. This can be a:

• ​central line​

• ​PICC line​

• ​portacath​

Or you might have treatment through a thin short tube (a cannula) that goes into a vein in your arm. You have a new cannula each time you have treatment.

You see the dentist for a check up before starting zoledronic acid.

What are the side effects of zoledronic acid?

Side effects can vary from person to person. They also depend on what other treatment you are having. 

When to contact your team

Your doctor, nurse, or pharmacist will go through the possible side effects. They will monitor you closely during treatment and check how you are at your appointments. Contact your advice line as soon as possible if:

• you have severe side effects 

• your side effects aren’t getting any better

• your side effects are getting worse

We haven't listed all the side effects here. Talk to your healthcare team if you have any new symptoms that you think might be a side effect of your treatment.

Remember it is very unlikely that you will have all of these side effects, but you might have some of them at the same time.

Common side effect

It’s common to get low phosphate levels in the blood with zoledronic acid. This side effect can happen in more than 10 in 100 people (more than 10%). You will have regular blood tests to check for this.

Occasional side effects

These side effects happen in between 1 and 10 out of every 100 people (between 1 and 10%). You might have one or more of them. They include:

• changes to how well your kidneys work- you have blood tests to monitor changes.it is important to drink plenty of fluids before and after your treatment.

• low calcium levels in the blood– you have regular blood tests to check on this. You have calcium and vitamin D supplements to take. You must take them as the doctor or nurse tells you to.

• headache

• flu like symptoms– such as shaking, tiredness, flushing and feeling generally unwell

• pain in different parts of your body such as your bones, muscles and joints

• general aches

• low red blood cell levels (anaemia)

• feeling or being sick

• loss of appetite

• high temperature

• red eyes (conjunctivitis) or sore eyes

Rare side effects

These side effects happen in fewer than 1 in 100 people (less than 1%). You might have one or more of them. They include:

• changes to your heartbeat

• allergic reaction that can cause a rash, shortness of breath, redness or swelling of the face and dizziness - some allergic reactions can be life threatening, alert your nurse or doctor if notice any of these symptoms

• blood pressure changes either low or high

• increased risk of getting an infection due to low levels of white blood cells in the blood

• bruising, bleeding gums, or nosebleeds due to low levels of platelets in the blood

• difficulty breathing and wheezing

• cough

• skin problems such as a rash, itchy skin or hives

• difficulty sleeping or feeling very sleepy

• dizziness

• sore or dry mouth

• diarrhoea or constipation

• nerve changes causing either increased sensitivity, numbness, tingling (pins and needles) or prickling

• tummy (abdominal) pain

• tremors

• anxiety

• eye problems such as blurred vision or inflammation

• increased sweating

• muscle cramps

• blood and protein in the urine

• pain, swelling, irritation, hardening or redness at the injection site

• chest pain

• weight gain

• low amounts of magnesium and potassium in the blood – you have regular blood tests to check on this

• changes to taste

• indigestion

• feeling weak and lacking in energy

• swelling of feet and hands (oedema)

• damage to the jaw bone (osteonecrosis)

Damage to the bones

Damage to the bones (for example in the jaw or thigh) is a rare but serious side effect. Healthy bone in the jaw becomes damaged and dies. This is called osteonecrosis. Contact your medical team if you have any of the following:

• ear pain

• discharge from your ear

• an ear infection

• pain in the mouth, teeth or jaw

• loosening of a tooth

• pain or weakness in your hip, thigh or groin

Find out more about damage to the jaw bone and what to do

What else do you need to know?

Other medicines, foods and drink

Cancer drugs can interact with medicines, herbal products, and some food and drinks. We are unable to list all the possible interactions that may happen. An example is grapefruit or grapefruit juice which can increase the side effects of certain drugs.

Tell your healthcare team about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies. Also let them know about any other medical conditions or allergies you may have.

Pregnancy and contraception

It is unknown whether treatment may or may not harm a baby developing in the womb. It is important not to become pregnant or get someone pregnant while you are having treatment. Let your team know straight away if you or your partner become pregnant while having treatment.

Talk to your doctor or nurse about effective contraception you can use during treatment. Ask how long you should use it before starting treatment and after treatment has finished.

Fertility

It is not known whether this treatment affects ​fertility​ in people. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.

Breastfeeding

It is not known whether this drug comes through into the breast milk. Doctors usually advise that you don’t breastfeed during this treatment.

Treatment for other conditions

If you are having tests or treatment for anything else, always mention your cancer treatment. For example, if you are visiting your dentist.