Avelumab (Bavencio)

Avelumab (also known as Bavencio) is a type of immunotherapy. You might have it as a treatment for:

• merkel cell carcinoma (MCC) that has spread to other parts of the body 

• a type of kidney cancer called renal cell cancer that has spread, you have it with another cancer drug called axitinib

• advanced urothelial cancers if you have had chemotherapy and your cancer hasn’t grown

Urothelial cancers include cancers of the:

• bladder

• ureters - the tubes that carry the urine from the kidneys to the bladder

• urethra - the tube that carries the urine from your bladder out of your body

How do you have avelumab?

You have avelumab as a drip into your bloodstream (intravenously). It takes about an hour each time you have it.

You can have the drug through a thin short tube (a cannula) that goes into a vein in your arm each time you have treatment.

Or you might have it through a long line: a central line, a PICC line or a portacath.

These are long plastic tubes that give the drug into a large vein in your chest. The tube stays in place throughout the course of treatment.

Find out more about long lines

Tests

You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver, thyroid and kidneys are working.

What are the side effects of avelumab?

Side effects can vary from person to person. They also depend on what other treatment you are having. 

When to contact your team

Your doctor, pharmacist or nurse will go through the possible side effects. They will monitor you closely during treatment and check how you are at your appointments. Contact your advice line as soon as possible if:

• you have severe side effects

• your side effects aren’t getting any better

• your side effects are getting worse

Early treatment can help manage side effects better. 

We haven't listed all the side effects here. Talk to your healthcare team if you have any new symptoms that you think might be a side effect of your treatment.

Remember it is very unlikely that you will have all of these side effects, but you might have some of them at the same time.

Common side effects

These effects happen in more than 10 in 100 people (more than 10%). You might have one or more of them. They include:

A reaction during the infusion

A reaction may happen during the infusion. Symptoms can include a skin rash, itching, swelling of the lips, face or throat, breathing difficulties, fever and chills. Your nurse will give you medicines beforehand to try to prevent a reaction. 

Diarrhoea and inflamed bowel

You might get diarrhoea. Try to eat small meals and snacks regularly. It’s best to try to have a healthy balanced diet if you can. You don’t necessarily need to stop eating foods that contain fibre. But if your diet is normally very high in fibre, it might help to cut back on high fibre foods such as beans, nuts, seeds, dried fruit, bran and raw vegetables. 

Drink plenty to try and replace the fluid lost. Aim for 8 to 10 glasses per day.

Your bowel may also become inflamed and swollen. This can be serious.

Tiredness

Tiredness and weakness (fatigue) can happen during and after treatment. Doing gentle exercises each day can keep your energy up. Don't push yourself, rest when you start to feel tired and ask others for help.

Let your doctor know if you are more tired than usual.

Loss of appetite and weight loss

You might not feel like eating and may lose weight. Eating several small meals and snacks throughout the day can be easier to manage. You can talk to a dietitian if you are concerned about your appetite or weight loss. 

Difficulty breathing and cough

You may have difficulty breathing or a cough. Let your doctor or nurse know straight away if you have these symptoms. They can give you medicine to help.

Breathlessness and looking pale

You might be breathless and look pale due to a drop in red blood cells. This is called anaemia.

Feeling or being sick

Feeling sick is usually mild. Anti sickness tablets can control it if you need them. Tell your doctor or nurse if you feel sick. 

Tummy (abdominal) pain

Tell your treatment team if you have this. They can check the cause and give you medicine to help. 

Pain in your back or joints

Let your doctor know if you have pain in your back or joints. There are lots of ways to treat pain, including painkillers and relaxation.

Constipation

​Constipation​ is easier to sort out if you treat it early. Drink plenty and eat as much fresh fruit and vegetables as you can. Try to take gentle exercise, such as walking. Tell your healthcare team if you think you are constipated. They can give you a laxative if needed.

High temperature

Tell your healthcare team straightaway if you get a high temperature. Ask them if you can take paracetamol to help lower your temperature.

Swollen hands and feet

Swelling of hands and feet is due to fluid build up. This is called oedema. Let your doctor or nurse know if you have any swelling.

Occasional side effects

These side effects happen in between 1 and 10 out of every 100 people (between 1 and 10%). You might have one or more of them. They include:

• low levels of white blood cells in your body which can increase your risk of getting an infection

• a drop in the levels of platelets in your body which can increase your risk of bruising, bleeding and nosebleeds

• headaches and dizziness - tell your doctor or nurse if you have these symptoms

• numbness and tingling in fingers and toes which can make it difficult doing up buttons

• changes to the levels of thyroid hormones in your body - low levels can make you feel tired and cold, high levels can cause other symptoms including heart palpitations

• high or low blood pressure

• inflammation of the lung tissue (pneumonitis)

• dry mouth

• skin changes such as a rash, itching and dry skin

• pain in your muscles

• flu like symptoms such as shivering, chills and feeling generally unwell

• higher levels of liver and pancreatic enzymes that are usually temporary and go back to normal once you stop treatment

• inflammation of your joints

• muscle weakness (Myasthenia gravis)

Rare side effects

These side effects happen in fewer than 1 in 100 people (fewer than 1%). You might have one or more of them. They include:

• high blood sugar levels (diabetes)

• inflammation in different parts of your body such as the heart, thyroid, eyes, bowel, liver and kidneys - you may need to take steroids or other treatments to help manage these side effects

• problems with your nerves that can cause numbness, weakness and pain

• low levels of different hormones in your body

What else do I need to know?

Other medicines, foods and drinks

Cancer drugs can interact with medicines, herbal products, and some food and drinks. We are unable to list all the possible interactions that may happen. An example is grapefruit or grapefruit juice which can increase the side effects of certain drugs.

Tell your healthcare team about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies. Also let them know about any other medical conditions or allergies you may have.

Loss of fertility

It is not known whether this treatment affects ​fertility​ in people. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.

Contraception and pregnancy

This drug may harm a baby developing in the womb. It is important not to become pregnant or get someone pregnant while you are having treatment with this drug and for at least a month afterwards.

Talk to your doctor or nurse about effective contraception before starting treatment. Let them know straight away if you or your partner become pregnant while having treatment.

Breastfeeding

It is not known whether this drug comes through into the breast milk. Doctors usually advise that you don’t breastfeed during this treatment.

Treatment for other conditions

If you are having tests or treatment for anything else, always mention your cancer treatment. For example, if you are visiting your dentist.

Immunisations

Don’t have immunisations with live vaccines while you’re having treatment and for up to 12 months afterwards. The length of time depends on the treatment you are having.

Ask your doctor or pharmacist how long you should avoid live vaccinations.

In the UK, live vaccines include rubella, mumps, measles, BCG, and yellow fever.

You can usually have:

• other vaccines, but they might not give you as much protection as usual

• the flu vaccine (as an injection)

• the coronavirus (COVID-19) vaccine

Talk to your doctor or pharmacist about the best time to have a vaccine in relation to your cancer treatment.

Contact with others who have had immunisations 

You can be in contact with other people who have had live vaccines as injections. If someone has had a live vaccine by mouth or nasal spray there may be a small risk the vaccine virus can be passed onto you if your ​immune system​ is weakened.

Your healthcare team will let you know if you need to take any precautions if you are in close contact with someone who has had a live vaccine.

Read more about immunisations and cancer treatment