Inherited cancer genes and increased cancer risk

Family history and inherited cancer genes

Most cancers are caused by gene changes that happen during our lifetime
Some people have an increased risk of particular types of cancer because they are born (inherited) with a gene change
Your doctor can refer you to a genetic clinic if you have a strong family history of cancer

This information looks at how inherited gene changes can cause cancer and what you can do if you have a strong family history of cancer.

How can genes cause cancer?

Inside almost every single cell in your body is a structure called the nucleus. The nucleus is the control centre of the cell. Inside the nucleus are 23 pairs of chromosomes made up of genes. Genes are coded messages that tell cells how to behave. They control how our bodies grow and develop. We each have about 20,000 genes.

All cancers develop because something has gone wrong with one or more of the genes in a cell. You may also hear gene changes called other terms such as gene:

alterations
variants
faults

These changes can make a cell stop working properly. It may then become cancerous and divide and grow uncontrollably. Most gene changes happen during our lifetime but we can inherit some from a parent.

Most cancers happen due to gene changes that develop during our lifetime. They usually happen as we get older due to random mistakes when a cell is dividing. Or they may happen because of something we are exposed to, such as cigarette smoke or sunlight. Doctors call these things carcinogens.

These gene changes don’t affect all body cells. They are not inherited and can't be passed on to our children. They are called acquired mutations. Cancers caused by acquired mutations are called sporadic cancers. They are the most common type of cancer.

Inherited cancer gene faults

Some faulty genes that increase the risk of cancer can be passed on from parent to child. These are inherited cancer gene changes. They occur when there is a change in the genes in an egg or sperm cell at the time of conception. These changes in the initial sperm or egg cell are copied into every single cell in the body. The gene changes can then pass from generation to generation. They are called germline mutations.

We inherit genes from both our parents. If a parent has a gene change, then each child has a 1 in 2 chance (50%) of inheriting it. So, some children will have the gene change and an increased risk of developing cancer and some children won’t.

Being born with inherited gene changes doesn’t mean that a person will definitely get cancer. But they have a higher risk of developing particular types of cancer than other people. They are also more likely to develop cancer at a younger age. Doctors call this having a genetic predisposition to cancer. For a cancer to develop, further gene changes (mutations) need to happen. This usually happens over many years.

How common are cancers caused by inherited gene changes?

Cancers due to inherited gene changes are much less common than cancers due to gene changes caused by ageing or other factors. Most cancers develop because of a combination of chance and our environment, not because we have inherited a specific cancer gene change.

Genetic specialists estimate that up to 12 in every 100 cancers (up to 12%) diagnosed are linked to an inherited gene change.

Different gene changes increase the risk of different types of cancer. Some changes increase the risk by a small amount and some increase the risk much more.

Read about inherited genes and cancer types.

A family history of cancer

Most people who have relatives with cancer will not have inherited a gene change. Cancer mostly occurs in older people. It is a common disease. Nearly 1 in 2 people in the UK (nearly 50%) born after 1960 will be diagnosed with some form of cancer during their lifetime. So, most families will have at least one person who has or has had cancer. Having a couple of relatives diagnosed with cancer doesn’t mean there is a cancer gene change running in the family.

In families with an inherited gene change, there is usually a pattern of specific types of cancer running in the family. The strength of your family history depends on:

who in your family has had cancer
the types of cancer they have had
how old they were at diagnosis
how closely related the relatives with cancer are to each other

The more relatives who have had the same or related types of cancer, and the younger they were at diagnosis, the stronger someone’s family history is. This means that it is more likely that the cancers are being caused by an inherited gene change.

This family tree shows a pattern of cancer that could be caused by an inherited gene change.

You may have a strong family history if some of the following situations apply to you:

the cancers developed when the family members were young – for example below the age of 50 for breast, bowel and womb cancer
multiple close relatives on the same side of your family have had cancer – the same side of your family means either your father’s relatives or your mother’s relatives
the relatives have had the same type of cancer, or different cancers that can be caused by the same gene fault
one of your relatives has had a gene change found by genetic tests

It is important to remember that cancer is most common in older people. Each year more than a third (36%) of all cancer cases in the UK are diagnosed in people aged 75 and over. Cancer in older people is less likely to be due to an inherited cancer gene.

What if I have a strong family history?

Talk to your GP if you think that you may have a strong family history of cancer. Your GP will ask you about your family and how many members have had cancer, so it is important to have as much information about your relatives’ cancer diagnoses as possible. For example they will ask about the type of cancer they had and the age they had it. If they think that you might be at increased risk, they can refer you to a genetics clinic.

Read about genetic testing for cancer risk.

What if I have a known gene change?

Your doctor or a genetic counsellor will be able to give you an idea of how much your cancer risk is increased compared to the general population. They might suggest that you have regular monitoring for particular cancers. Or treatment such as surgery to try to reduce the risk of developing cancer.

You can find out more about the options if you have a known gene change on our page about getting your genetic test results.

Gene changes and other factors

Some inherited cancer genes are more likely to cause cancer than others. As well as a gene change, many other factors need to be in place for a cancer to develop. Because of this, the effect of the cancer gene may appear to skip a generation. For example, a parent may have the gene change and not develop cancer but their child who inherits the same gene change does develop cancer.

Researchers need to find out more about what these other factors are for each type of cancer. They are also trying to find out more about how genes work together to cause cancer so that we can reduce the risk of developing it.